Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder

doi:10.1097/PSY.0000000000001293

	Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder
	Zhang, Jian-Jun1,2 ; Wang, Jingxia 3; Wang, Xiao-Qian 1; Zhang, Xiang-Yang2,4,5
通讯作者	Zhang, Xiang-Yang([email protected])
摘要	Objective Major depressive disorder (MDD) is a severe psychiatric symptom worldwide, and the coexistence of MDD with metabolic syndrome (MetS) is common in clinical practice. However, gender differences in comorbid MetS in first-episode and drug-naive (FEDN) MDD patients have not been reported. Here, we explored potential gender differences in the prevalence and clinical correlates of comorbid MetS in FEDN MDD patients. Methods A cross-sectional study of 1718 FEDN MDD patients was conducted. Demographic and clinical data were collected. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale, and Positive and Negative Syndrome Scale positive subscale were used to evaluate depression, anxiety, and psychotic symptoms, respectively. Results The prevalence of MetS was 1.645-fold higher in female MDD patients (38.50%) than in male patients (26.53%). Patients with MetS had higher HAMD score, Hamilton Anxiety Scale score, and Positive and Negative Syndrome Scale positive subscale score than patients without MetS (p values < .001). Furthermore, suicide attempts (male: odds ratio [OR] = 1.706, p = .034; female: OR = 1.639, p = .004) and HAMD score (male: OR = 1.251, p < .001; female: OR = 1.148, p < .001) were independently associated with MetS in male and female patients, whereas age of onset was independently associated with MetS only in female patients (OR = 1.744, p = .047). Conclusions Our findings suggest significant gender differences in the prevalence and clinical correlates of comorbid MetS in FEDN MDD patients. Clinical variables (suicide attempts and HAMD scores) may be independently associated with MetS in MDD patients.
关键词	gender differences major depressive disorder metabolic syndrome first-episode and drug-naive patients
	2024-04-01
语种	英语
DOI	10.1097/PSY.0000000000001293
发表期刊	PSYCHOSOMATIC MEDICINE
ISSN	0033-3174
卷号	86 期号:3 页码:202-209
收录类别	SCI
资助项目	Chinese National Programs for Brain Science and Brain-like Intelligence Technology[2021ZD0202102] ; National Natural Science Foundation of China[31871111] ; Shanxi Provincial Key Team for Science and Technology Innovation in Traditional Chinese Medicine Prevention and Treatment of Encephalopathy and New Drug Development[2013131022]
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS关键词	HORMONE-BINDING GLOBULIN ; MENTAL-HEALTH SURVEY ; SEX-DIFFERENCES ; GENERAL-POPULATION ; SERUM TESTOSTERONE ; SOMATIC SYMPTOMS ; RISK-FACTORS ; OBESITY ; WOMEN ; AGE
WOS研究方向	Psychiatry ; Psychology
WOS类目	Psychiatry ; Psychology ; Psychology, Multidisciplinary
WOS记录号	WOS:001198478600004
资助机构	Chinese National Programs for Brain Science and Brain-like Intelligence Technology ; National Natural Science Foundation of China ; Shanxi Provincial Key Team for Science and Technology Innovation in Traditional Chinese Medicine Prevention and Treatment of Encephalopathy and New Drug Development
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/47682
专题	中国科学院心理健康重点实验室
通讯作者	Zhang, Xiang-Yang
作者单位	1.Shanxi Univ Chinese Med, Natl Int Joint Res Ctr Mol Chinese Med, Shanxi Key Lab Chinese Med Encephalopathy, Jinzhong, Peoples R China 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Sch Nursing, Tianjin, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhang, Jian-Jun,Wang, Jingxia,Wang, Xiao-Qian,et al. Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder[J]. PSYCHOSOMATIC MEDICINE,2024,86(3):202-209.
APA	Zhang, Jian-Jun,Wang, Jingxia,Wang, Xiao-Qian,&Zhang, Xiang-Yang.(2024).Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder.PSYCHOSOMATIC MEDICINE,86(3),202-209.
MLA	Zhang, Jian-Jun,et al."Gender Differences in the Prevalence and Clinical Correlates of Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major Depressive Disorder".PSYCHOSOMATIC MEDICINE 86.3(2024):202-209.