The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus

doi:10.1007/s11682-024-00940-4

	The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus
	Hu, Yuanyuan 1,2; Zhao, Jingjie 3; Jin, Yuening1,2 ; Du, Yi3 ; Zhao, Qian 3; Xu, Shuai 3; Li, Li 3; Zhou, Yuan1,2,4
通讯作者	Zhou, Yuan([email protected])
摘要	Globus Pharyngeus (GP) is a somatic symptom that accompanies mood distress. Although the etiology of GP remains unclear, its specific symptom of a false lump sensation in the throat without physical obstruction raises the possibility of alterations in brain networks responsible for somatosensory and emotion processing in patients with GP. To address this possibility, we investigated resting-state functional connectivity (rsFC) in 31 patients with GP and 24 healthy individuals using resting-state functional magnetic resonance imaging. Considering its significance in somatosensory and emotional functions, we focused on rsFC in the subregions of the thalamus. We found significantly decreased rsFC between the right caudal temporal thalamus (rcTtha) and the midcingulate cortex (MCC) as well as significantly decreased rsFC between the right rostral temporal thalamus (rrTtha) and the left cerebellum in the patients with GP. Additionally, within the patient group, the abnormalities in rsFC between the rcTtha and the MCC were correlated with the severity of somatization symptoms but not with depression and anxiety. These findings suggest alterations in the rsFC of thalamic subregions in patients with GP, shedding light on the pathogenesis of GP and potentially leading to improved diagnosis and treatment approaches for the condition.
关键词	Globus Pharyngeus Resting-state functional magnetic resonance imaging Functional connectivity Thalamus
	2024-10-17
语种	英语
DOI	10.1007/s11682-024-00940-4
发表期刊	BRAIN IMAGING AND BEHAVIOR
ISSN	1931-7557
页码	9
收录类别	SCI
资助项目	National Natural Science Foundation of China[82004109] ; National Natural Science Foundation of China[81673737] ; National Natural Science Foundation of China
出版者	SPRINGER
WOS关键词	CINGULATE CORTEX ; ANXIETY DISORDER ; PAIN ; DEPRESSION ; ETIOLOGY ; CYTOARCHITECTURE ; SEVERITY ; VALIDITY
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:001334460400001
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/49122
专题	中国科学院行为科学重点实验室
通讯作者	Zhou, Yuan
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Capital Med Univ, Beijing Friendship Hosp, Dept Tradit Chinese Med, Beijing 100050, Peoples R China 4.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
第一作者单位	中国科学院行为科学重点实验室
通讯作者单位	中国科学院行为科学重点实验室
推荐引用方式 GB/T 7714	Hu, Yuanyuan,Zhao, Jingjie,Jin, Yuening,et al. The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus[J]. BRAIN IMAGING AND BEHAVIOR,2024:9.
APA	Hu, Yuanyuan.,Zhao, Jingjie.,Jin, Yuening.,Du, Yi.,Zhao, Qian.,...&Zhou, Yuan.(2024).The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus.BRAIN IMAGING AND BEHAVIOR,9.
MLA	Hu, Yuanyuan,et al."The altered resting-state functional connectivity of thalamic subregions in patients with globus pharyngeus".BRAIN IMAGING AND BEHAVIOR (2024):9.