Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals

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	Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals
	Yuan, Yi 2,3; Zhu, Zude 4; Shi, Jinfu 2; Zou, Zhiling5 ; Yuan, Fei 6; Liu, Yijun 7,8; Lee, Tatia M. C.1; Weng, Xuchu2 ; Tatia M.C. Lee
摘要	Numerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage.; Numerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage. (C) 2009 Elsevier Inc. All rights reserved.
关键词	Heroin Addiction Gray matter VBM
学科领域	变态心理学
	2009-12-01
语种	英语
发表期刊	BRAIN AND COGNITION
ISSN	0278-2626
卷号	71 期号:3 页码:223-228
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS记录号	WOS:000271664400006
引用统计	被引频次：114[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5439
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Tatia M.C. Lee
作者单位	1.Univ Hong Kong, Neuropsychol Lab, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Lab Higher Brain Funct, Inst Psychol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China 4.S China Normal Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China 5.SW China Normal Univ, Dept Psychol, Chongqing, Peoples R China 6.Wujing Med Coll, Dept Radiol, Tianjin, Peoples R China 7.Univ Florida, Dept Psychiat, Gainesville, FL 32610 USA 8.Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA
推荐引用方式 GB/T 7714	Yuan, Yi,Zhu, Zude,Shi, Jinfu,et al. Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals[J]. BRAIN AND COGNITION,2009,71(3):223-228.
APA	Yuan, Yi.,Zhu, Zude.,Shi, Jinfu.,Zou, Zhiling.,Yuan, Fei.,...&Tatia M.C. Lee.(2009).Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals.BRAIN AND COGNITION,71(3),223-228.
MLA	Yuan, Yi,et al."Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals".BRAIN AND COGNITION 71.3(2009):223-228.

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