Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication

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	Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication
	Tang, Kai-Fu 1; Xie, Jing 1; Chen, Min 1; Liu, Qi 1; Zhou, Xi-Yuan 2; Zeng, Weiqun 1; Huang, Ai-Long 1; Zuo, Guo-qing 3; Wang, Yan 4; Xiang, Rong 5; Ren, Hong 1; K. F. Tang ; H. Ren
摘要	Recent studies have demonstrated that the effect of inhibition of HBV replication can be achieved by RNA interference (RNAi) at both the cellular and organismal levels. However, HBV replication cannot be completely inhibited by this method. To completely inhibit HBV replication, new strategies for improving the inhibition efficacy of HBV-specific siRNAs are needed. In this study, we demonstrated that knockdown of damage-specific DNA binding protein 1 (DDB1), a protein involved in nucleotide-excision repair and HBV replication, significantly enhanced the HBx-siRNA-mediated inhibition of HBV replication. Although knockdown of DDB1 may be toxic to normal liver cells, our results indeed suggest a new direction to enhance the efficacy of HBV-siRNA-mediated inhibition of HBV replication.; Recent studies have demonstrated that the effect of inhibition of HBV replication can be achieved by RNA interference (RNAi) at both the cellular and organismal levels. However, HBV replication cannot be completely inhibited by this method. To completely inhibit HBV replication, new strategies for improving the inhibition efficacy of HBV-specific siRNAs are needed. In this study, we demonstrated that knockdown of damage-specific DNA binding protein 1 (DDB1), a protein involved in nucleotide-excision repair and HBV replication, significantly enhanced the HBx-siRNA-mediated inhibition of HBV replication. Although knockdown of DDB1 may be toxic to normal liver cells, our results indeed suggest a new direction to enhance the efficacy of HBV-siRNA-mediated inhibition of HBV replication. (C) 2007 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.
关键词	hepatitis B virus RNAi damage-specific DNA binding protein 1
学科领域	分子生物学
	2008-05-01
语种	英语
发表期刊	BIOLOGICALS
ISSN	1045-1056
卷号	36 期号:3 页码:177-183
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000255548000004
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5513
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	K. F. Tang; H. Ren
作者单位	1.Chongqing Univ Med Sci, Affiliated Hosp 2, Inst Viral Hepatitis, Minist Educ,Key Lab Mol Biol Infect Dis, Chongqing 400010, Peoples R China 2.Chongqing Med Univ, Affiliated Hosp 2, Dept Ophthalmol, Chongqing 400010, Peoples R China 3.Chongqing Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Chongqing 400010, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 5.Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
推荐引用方式 GB/T 7714	Tang, Kai-Fu,Xie, Jing,Chen, Min,et al. Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication[J]. BIOLOGICALS,2008,36(3):177-183.
APA	Tang, Kai-Fu.,Xie, Jing.,Chen, Min.,Liu, Qi.,Zhou, Xi-Yuan.,...&H. Ren.(2008).Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication.BIOLOGICALS,36(3),177-183.
MLA	Tang, Kai-Fu,et al."Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication".BIOLOGICALS 36.3(2008):177-183.

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