Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| Neuroimaging activation studies in the vegetative state: predictors of recovery? | |
Di, Haibo1,2,3; Boly, Melanie1,2; Weng, Xuchu4 ; Ledoux, Didier1,2; Laureys, Steven1,2
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| 摘要 | The vegetative state (VS) is a devastating clinical condition characterised by wakefulness without awareness. Functional neuroimaging permits to objectively measure brain responsiveness to external stimuli in VS. The literature on functional magnetic resonance imaging and positron emission tomography studies in these patients has been reviewed. Results from 15 studies were classified in: absent cortical activation or 'typical' activation of 'low level' primary sensory cortices and 'atypical' activation spreading to 'higher level' associative cortices. This descriptive review on 48 published cases suggests that 'atypical' activation patterns seem to herald recovery from VS with a 93% specificity and 69% sensitivity. Passive stimulation paradigms, however, do not permit to make strong claims about the absence or presence of consciousness. Recently proposed mental imagery paradigms permit to identify signs of consciousness in non-communicative brain damaged patients. The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness.; The vegetative state (VS) is a devastating clinical condition characterised by wakefulness without awareness. Functional neuroimaging permits to objectively measure brain responsiveness to external stimuli in VS. The literature on functional magnetic resonance imaging and positron emission tomography studies in these patients has been reviewed. Results from 15 studies were classified in: absent cortical activation or 'typical' activation of 'low level' primary sensory cortices and 'atypical' activation spreading to 'higher level' associative cortices. This descriptive review on 48 published cases suggests that 'atypical' activation patterns seem to herald recovery from VS with a 93% specificity and 69% sensitivity. Passive stimulation paradigms, however, do not permit to make strong claims about the absence or presence of consciousness. Recently proposed mental imagery paradigms permit to identify signs of consciousness in non-communicative brain damaged patients. The clinical application of these functional neuroimaging techniques awaits validation from ongoing multi-centric cohort studies in these challenging patients with chronic disorders of consciousness. |
| 关键词 | brain injury coma functional magnetic resonance imaging minimally conscious state positron emission tomography vegetative state |
| 学科领域 | 医学心理学 ; 认识神经科学 |
| 2008-10-01 | |
| 语种 | 英语 |
| 发表期刊 | CLINICAL MEDICINE
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| ISSN | 1470-2118 |
| 卷号 | 8期号:5页码:502-507 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS记录号 | WOS:000260039700009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/5579 |
| 专题 | 中国科学院心理研究所回溯数据库(1956-2010) |
| 作者单位 | 1.Univ Liege, Coma Sci Grp, Cyclotron Res Ctr, B-4000 Liege, Belgium 2.Univ Liege, Dept Neurol, B-4000 Liege, Belgium 3.Hangzhou Normal Univ, Hangzhou, Zhejiang, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Di, Haibo,Boly, Melanie,Weng, Xuchu,et al. Neuroimaging activation studies in the vegetative state: predictors of recovery?[J]. CLINICAL MEDICINE,2008,8(5):502-507. |
| APA | Di, Haibo,Boly, Melanie,Weng, Xuchu,Ledoux, Didier,&Laureys, Steven.(2008).Neuroimaging activation studies in the vegetative state: predictors of recovery?.CLINICAL MEDICINE,8(5),502-507. |
| MLA | Di, Haibo,et al."Neuroimaging activation studies in the vegetative state: predictors of recovery?".CLINICAL MEDICINE 8.5(2008):502-507. |
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