Neurological abnormalities in Chinese schizophrenic patients

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	Neurological abnormalities in Chinese schizophrenic patients
	Chan, Raymond C. K.; Chen, Eric Y. H.; R. C. K. Chan
摘要	Background: This study attempted to examine the prevalence and type of neurological signs in Chinese patients with schizophrenia. Methods: A cross-sectional design was adopted with the use of the Cambridge Neurological Inventory (CNI). The CNI is comprised of 7 subscales, including motor coordination, sensory integration, disinhibition, extrapyramidal signs, dyskinesia, catatonia, and pyramidal signs. The former 3 subscales were classified as soft signs, whereas the latter 4 subscales were classified as hard signs. A total of 250 Chinese schizophrenic patients and 90 normal controls were recruited. Results: Patients exhibited significantly more signs than normal controls in all subscales but pyramidal signs (p < 0.00005). Significant differences were also found in total soft signs, total hard signs as well as total neurological signs (p < 0.0005). The three subscales of soft signs showed a relatively better sensitivity and specificity as compared with the four subscales of hard signs. Improvement in sensitivity and specificity was demonstrated when the subscales were collapsed into total soft signs, total hard signs and total neurological signs. A cut-off of 4 in total soft signs yields a sensitivity of 0:63 and specificity of 0.71; whereas a cut-off of I in total hard signs yields a sensitivity of 0.78 and specificity of 0.89. A global cut-off of 5 in total neurological signs results in a sensitivity of 0.81 and specificity of 0.73 for detecting schizophrenia versus normal. Conclusions: High levels of neurological abnormality characterize schizophrenic patients. An extended assessment battery of CNI provides even better discrimination of patients from normal controls, and soft signs are more strongly associated with schizophrenia than are hard signs in the Chinese sample.; Background: This study attempted to examine the prevalence and type of neurological signs in Chinese patients with schizophrenia.
关键词	neurological signs prevalence Cambridge neurological inventory schizophrenia Chinese
学科领域	精神病学
	2007
语种	英语
发表期刊	BEHAVIOURAL NEUROLOGY
ISSN	0953-4180
卷号	18 期号:3 页码:171-181
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000249670900006
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5583
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	R. C. K. Chan
作者单位	1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Chan, Raymond C. K.,Chen, Eric Y. H.,R. C. K. Chan. Neurological abnormalities in Chinese schizophrenic patients[J]. BEHAVIOURAL NEUROLOGY,2007,18(3):171-181.
APA	Chan, Raymond C. K.,Chen, Eric Y. H.,&R. C. K. Chan.(2007).Neurological abnormalities in Chinese schizophrenic patients.BEHAVIOURAL NEUROLOGY,18(3),171-181.
MLA	Chan, Raymond C. K.,et al."Neurological abnormalities in Chinese schizophrenic patients".BEHAVIOURAL NEUROLOGY 18.3(2007):171-181.

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