Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress

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	Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress
	Guo, Jian-You2 ; Huo, Hai-Ru 1; Li, Lan-Fang 1; Guo, Shu-Ying 1; Jiang, Ting-Liang 1; H. R. Huo
摘要	Sini Tang, a Chinese traditional prescription containing three herbs, has been widely used for Yang-deficiency. Recent clinical studies have shown that Sini Tang could treat and improve depression symptoms, but the mechanisms underlying the antidepressant effect of Sini Tang remains unknown. In rats with chronic unpredictable stress (CUS), we examined the effects of Sini Tang on sucrose preference and open field exploratory behavior. The levels of corticosterone level in plasma and corticotropin-releasing hormone (CRH) mRNA expression in hypothalamus were also measured by enzyme-linked immunosorbent assays (ELISA) and real-time reverse transcription PCR (RT-PCR), respectively. Rats subjected to CUS exhibited decreases in sucrose preference and ambulation in the open field test. These were all attenuated by Sini Tang in a dose-dependent manner. Biochemically, Sini Tang also reversed CUS-induced increases in corticosterone in plasma and CRH mRNA in the hypothalamus. The behavioral effects of the Sini Tang were correlated to the biochemical actions. These results suggest that Sini Tang produces an antidepressant-like effect, which appears to involve CRH in the brain.; Sini Tang, a Chinese traditional prescription containing three herbs, has been widely used for Yang-deficiency. Recent clinical studies have shown that Sini Tang could treat and improve depression symptoms, but the mechanisms underlying the antidepressant effect of Sini Tang remains unknown. In rats with chronic unpredictable stress (CUS), we examined the effects of Sini Tang on sucrose preference and open field exploratory behavior. The levels of corticosterone level in plasma and corticotropin-releasing hormone (CRH) mRNA expression in hypothalamus were also measured by enzyme-linked immunosorbent assays (ELISA) and real-time reverse transcription PCR (RT-PCR), respectively. Rats subjected to CUS exhibited decreases in sucrose preference and ambulation in the open field test. These were all attenuated by Sini Tang in a dose-dependent manner. Biochemically, Sini Tang also reversed CUS-induced increases in corticosterone in plasma and CRH mRNA in the hypothalamus. The behavioral effects of the Sini Tang were correlated to the biochemical actions. These results suggest that Sini Tang produces an antidepressant-like effect, which appears to involve CRH in the brain.
关键词	Depression Chronic Unpredictable Stress Corticotropin-releasing Hormone Corticosterone Radix aconiti lateralis preparata Rhizoma zingiberis recens Leguminosae
学科领域	生理心理学/生物心理学
	2009
语种	英语
发表期刊	AMERICAN JOURNAL OF CHINESE MEDICINE
ISSN	0192-415X
卷号	37 期号:2 页码:261-272
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000265207300006
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5689
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	H. R. Huo
作者单位	1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Guo, Jian-You,Huo, Hai-Ru,Li, Lan-Fang,et al. Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2009,37(2):261-272.
APA	Guo, Jian-You,Huo, Hai-Ru,Li, Lan-Fang,Guo, Shu-Ying,Jiang, Ting-Liang,&H. R. Huo.(2009).Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress.AMERICAN JOURNAL OF CHINESE MEDICINE,37(2),261-272.
MLA	Guo, Jian-You,et al."Sini Tang Prevents Depression-Like Behavior in Rats Exposed to Chronic Unpredictable Stress".AMERICAN JOURNAL OF CHINESE MEDICINE 37.2(2009):261-272.

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