The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese
	Qu, Yanchun 1,2,3; Yang, Ze 1; Jin, Feng4 ; Sun, Liang 2; Feng, Jie 1; Tang, Lei 1; Zhang, Chuanfang 2,3; Zhu, Xiaoquan 1; Shi, Xiaohong 1; Sun, Hong 5; Wang, Binyou 5; Wang, Li2 ; Z. Yang ; L. Wang
摘要	Leptin receptor (LEPR) plays an important physiological role in energy metabolism. The study addressed the relationship between leptin receptor gene variations and type 2 diabetes mellitus (T2DM). Three single nucleotide polymorphisms (SNPs) of LEPR gene, Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were detected in a northern population in China. Totally, 317 patients with T2DM and 282 healthy controls were recruited randomly from urban communities in Harbin area in the Northeast of China. All polymorphisms were genotyped by Sequenom SNP detection system in both case and control groups. Linkage disequilibria analysis showed moderate linkage disequilibria between the pair-wise SNPs for all three SNPs. Then, we identified the haplotype covering the three SNPs (AGC) with higher risk of T2DM (OR = 1.69 (1.09–2.61)), and showed that there existed significant difference between cases and controls (9.8% vs. 6.0%, P = 0.02). We also observed significant difference in frequencies of the heterozygous haplotype combination (GGT/AGC), that is 17.0% vs. 8.2% in cases and controls, respectively (P = 0.001). It further supported the evidence that the haplotype (AGC) was associated with T2DM. So, AGC haplotype in LEPR gene could be a risk factor associated with T2DM in Northern Chinese.; Leptin receptor (LEPR) plays an important physiological role in energy metabolism. The study addressed the relationship between leptin receptor gene variations and type 2 diabetes mellitus (T2DM). Three single nucleotide polymorphisms (SNPs) of LEPR gene, Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were detected in a northern population in China. Totally, 317 patients with T2DM and 282 healthy controls were recruited randomly from urban communities in Harbin area in the Northeast of China. All polymorphisms were genotyped by Sequenom SNP detection system in both case and control groups. Linkage disequilibria analysis showed moderate linkage disequilibria between the pair-wise SNPs for all three SNPs. Then, we identified the haplotype covering the three SNPs (AGC) with higher risk of T2DM (OR = 1.69 (1.09-2.61)), and showed that there existed significant difference between cases and controls (9.8% vs. 6.0%, P = 0.02). We also observed significant difference in frequencies of the heterozygous haplotype combination (GGT/AGC), that is 17.0% vs. 8.2% in cases and controls, respectively (P = 0.001). it further supported the evidence that the haplotype (AGC) was associated with T2DM. So, AGC haplotype in LEPR gene could be a risk factor associated with T2DM in Northern Chinese. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
关键词	haplotype LEPR gene type 2 diabetes case-control
学科领域	分子生物学
	2008-07-01
语种	英语
发表期刊	DIABETES RESEARCH AND CLINICAL PRACTICE
ISSN	0168-8227
卷号	81 期号:1 页码:33-37
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000257567000006
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5763
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Z. Yang; L. Wang
作者单位	1.Beijing Hosp, Minist Hlth, Natl Inst Geriatr, Beijing 100730, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 5.Harbin Med Coll, Sch Publ Hlth, Harbin 150081, Peoples R China
推荐引用方式 GB/T 7714	Qu, Yanchun,Yang, Ze,Jin, Feng,et al. The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2008,81(1):33-37.
APA	Qu, Yanchun.,Yang, Ze.,Jin, Feng.,Sun, Liang.,Feng, Jie.,...&L. Wang.(2008).The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese.DIABETES RESEARCH AND CLINICAL PRACTICE,81(1),33-37.
MLA	Qu, Yanchun,et al."The haplotype identified in LEPR gene is associated with type 2 diabetes mellitus in Northern Chinese".DIABETES RESEARCH AND CLINICAL PRACTICE 81.1(2008):33-37.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Qu-2008-The haplotyp（160KB）			开放获取	--	浏览下载