中国科学院心理研究所机构知识库

目的 探讨维持性血液透析(MHD)患者记忆执行功能.方法 运用连线测验、Go-No/Go测验、Stroop颜色命名测验等,比较40例MHD患者和40名正常健康人(NC)的认知计划能力及抑制能力.两组平均年龄和受教育程度差异均无统计学意义.结果 MHD组的连线测验A、B成绩显著差于Nc组(t_(连线A)=6.52,P<0.01;t_(连线B)=5.27,P<0.01).MHD组Go-No/Go测验基线水平显著低于NC组(t:3.27,P<0.01).MHD组的Stroop干扰效应更明显(t=3.30,P<0.01).Stroop色字测验中.NC组表现出显著的Stroop效应、重复分心物促进效应和负启动效应,MHD组只表现Stroop效应.两组的Stroop效应差异有统计学意义(t=2.41,P<0.05).结论 MHD患者执行功能中的认知计划能力、抑制能力均受损,其执行功能的病理性损伤独立于生理性衰老过程.

Objective To investigate the executive function(planning and inhibition)in maintenance hemodialysis(MHD)patients.Methods Neuropsychological research methods,including trail making test(A and B),Go-No/Go test and Stroop color naming task,were applied to examine 40 MHD patients and 40 healthy people(NC group).The mean age and education level of two groups were not significantly different.Results MHD group had significantly lower performance of trail making test A and B than NC group(t_A=6.52,P<0.01; t_B=5.27,P<0.01).MHD group had less scores on baseline condition of Go-No/Go test(t=3.27,P<0.01)and Stroop color naming test(t=3.30,P<0.01)than NC group.In Stroop color naming task test,NC group showed Stroop effect,significant repeated distraction promotion effect and significant negative priming effect,while MHD group showed only Stroop effect.There was significant difference in Stroop effect between MHD group and NC group(t=2.41,P<0.05).Conclusion Cognitive planning ability and inhibition ability of MHD patients are impaired.This pathological change of executive function in MHD patients is independent of normal aging process.