The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats

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	The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats
	Wang, Wei1 ; Qi, Wei-Jing1,2 ; Xu, Yang1 ; Wang, Jin-Yan1 ; Luo, Fei1 ; Wang JY(王锦琰); Luo F(罗非)
摘要	Although it has been accepted that depression and pain are common comorbidities, their interaction is not fully understood. The current study was aimed to investigate the effects of depression on both evoked pain behavior (thermal-induced nociception) and spontaneous pain behavior (formalin pain) using an olfactory bulbectomy (OB) rat model of depression. Emotional behaviors were assessed by open field and Morris water maze tests. The results showed that the depressed rats exhibited stronger tolerance to noxious thermal stimulation compared to non-depressed animals. In contrast, the spontaneous nociceptive behaviors induced by formalin injection were significantly enhanced in the OB rats in comparison to control rats. These results demonstrated that depression can have differential effects on stimulus-evoked pain and spontaneous pain, with alleviation in the former while aggravation in the latter. The present study has confirmed our previous findings that depression can inhibit evoked pain but facilitate spontaneous pain, and provides evidence that the OB depression model is a feasible model for studying the relationship between depression and pain. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
关键词	Depression Evoked pain Formalin Olfactory bulbectomy
学科领域	认知神经科学
	2010-03-19
语种	英语
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	472 期号:2 页码:143-147
期刊论文类型	Article
收录类别	SCI
资助项目	一室罗非课题组
WOS记录号	WOS:000276300300014
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/7241
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Wang JY(王锦琰); Luo F(罗非)
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Wang, Wei,Qi, Wei-Jing,Xu, Yang,et al. The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats[J]. NEUROSCIENCE LETTERS,2010,472(2):143-147.
APA	Wang, Wei.,Qi, Wei-Jing.,Xu, Yang.,Wang, Jin-Yan.,Luo, Fei.,...&罗非.(2010).The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats.NEUROSCIENCE LETTERS,472(2),143-147.
MLA	Wang, Wei,et al."The differential effects of depression on evoked and spontaneous pain behaviors in olfactory bulbectomized rats".NEUROSCIENCE LETTERS 472.2(2010):143-147.

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