i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study

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	i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study
	Zhang, Kunlin; Cui, Sijia; Chang, Suhua; Zhang, Liuyan; Wang, Jing; Wang J(王晶)
摘要	Genome-wide association study (GWAS) is nowadays widely used to identify genes involved in human complex disease. The standard GWAS analysis examines SNPs/genes independently and identifies only a number of the most significant SNPs. It ignores the combined effect of weaker SNPs/genes, which leads to difficulties to explore biological function and mechanism from a systems point of view. Although gene set enrichment analysis (GSEA) has been introduced to GWAS to overcome these limitations by identifying the correlation between pathways/gene sets and traits, the heavy dependence on genotype data, which is not easily available for most published GWAS investigations, has led to limited application of it. In order to perform GSEA on a simple list of GWAS SNP P-values, we implemented GSEA by using SNP label permutation. We further improved GSEA (i-GSEA) by focusing on pathways/gene sets with high proportion of significant genes. To provide researchers an open platform to analyze GWAS data, we developed the i-GSEA4GWAS (improved GSEA for GWAS) web server. i-GSEA4GWAS implements the i-GSEA approach and aims to provide new insights in complex disease studies. i-GSEA4GWAS is freely available at http://gsea4gwas.psych.ac.cn/.
学科领域	生理心理学/生物心理学
	2010-07-01
语种	英语
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	38 期号:suppl 2 页码:W90-W95
期刊论文类型	Article
收录类别	SCI
资助项目	一室王晶课题组
WOS记录号	WOS:000284148900016
引用统计	被引频次：146[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/7245
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Wang J(王晶)
作者单位	Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhang, Kunlin,Cui, Sijia,Chang, Suhua,et al. i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study[J]. NUCLEIC ACIDS RESEARCH,2010,38(suppl 2):W90-W95.
APA	Zhang, Kunlin,Cui, Sijia,Chang, Suhua,Zhang, Liuyan,Wang, Jing,&王晶.(2010).i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study.NUCLEIC ACIDS RESEARCH,38(suppl 2),W90-W95.
MLA	Zhang, Kunlin,et al."i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study".NUCLEIC ACIDS RESEARCH 38.suppl 2(2010):W90-W95.

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