中国科学院心理研究所机构知识库

以给予经定时喂水训练大鼠空瓶刺激为情绪性心理应激源，研究了此情绪应激对大鼠特异性原发体液免疫反应的影响及其可能的作用机制。结果表明每次10分钟，共14次的情绪应激显著低大鼠抗特异性抗原OVA的抗体水平及脾脏指数，而显著增高血肾上腺素、去甲肾上腺素和皮质酮水平。研究还发现去甲肾上腺素与抗特异性抗原OVA的抗体水平呈显著负相关。该研究证实了情绪性心理应激对大鼠体液免疫功能的抑制作用，并提示交感神经系统可能参与了此免疫调节作用。

The effect of exposure to emotional stress on the primary humoral immune function(antiovallum antibody level and spleen index), the endocrine response (corticosterone level, epinephrine and norepinephrine levels), the behavioral changes (exploring, grooming and attacking behavior) was studied in adult male Wistar rats. Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at two set times each day. Emotional stress were given 14 times, ten minutes per each time during experimental period. Results showed that firstly, empty water bottles induced significant attacking behavior (biting the empty water bottle and cage shed) in rats of emotional stress group, secondly emotional stress decreased the weight of the spleen and the level of specific anti-OVA IgG antibody and increased the levels of epinephrine, norepinephrine and corticosterone. A negative correlation between antibody levels and level of norepinephrine was also found. Together with the previous work in our laboratory, the results demonstrated that emotional stress suppressed the specific primary humoral immunity of rats. The sympathetic nervous system may be involved in this immunomodulation.