Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats

	Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats
	Li, Chun-Lu1,2 ; Zhu, Ning 1; Meng, Xiao-Lu1,2 ; Li, Yong-Hui1 ; Sui, Nan1 ; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Recent studies have indicated that the insula underlies affective learning. Although affective learning is well-established in the development of opiate addiction, the role of insula in this context remains unclear. To elucidate the organization of opiate-related affective learning within the insular cortex, we reversibly inactivated each of two major subdivisions of the insula in rats and tested the effects of this inactivation on the acquisition of morphine-induced conditioned place preference (CPP) and conditioned place aversion (CPA) induced by naloxone-precipitated acute morphine withdrawal. Results showed that inactivation of the primary interoceptive posterior granular insula (GI), but not that of the high-order anterior agranular insula (AI), disrupted the acquisition of CPP and that both GI and AI inactivation impaired the acquisition of CPA. These data suggest that the insular cortex is involved in positive and negative affective learning related to opiate addiction. In particular, the GI appears to be critical for both forms of affective learning, whereas the AI is crucial for learning associated with negative affects induced by opiate withdrawal.
关键词	Morphine naloxone agranular granular insular cortex conditioned place preference conditioned place aversion
学科领域	Physiological Psychology/biological Psychology
	2013
语种	英语
发表期刊	JOURNAL OF PSYCHOPHARMACOLOGY
ISSN	0269-8811
卷号	27 期号:9 页码:837-844
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	The study was supported by the Chinese Academy of Sciences (KSCX2-EW-R-12), the National Basic Research Program (2009CB522002), the National Natural Science Foundation (31170988, 31200770), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号	WOS:000323644300009
资助机构	Chinese Academy of Sciences [KSCX2-EW-R-12] ; National Basic Research Program [2009CB522002] ; National Natural Science Foundation [31170988, 31200770] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10634
专题	中国科学院心理健康重点实验室
通讯作者	Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Chun-Lu,Zhu, Ning,Meng, Xiao-Lu,et al. Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2013,27(9):837-844.
APA	Li, Chun-Lu,Zhu, Ning,Meng, Xiao-Lu,Li, Yong-Hui,Sui, Nan,&Sui, N .(2013).Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats.JOURNAL OF PSYCHOPHARMACOLOGY,27(9),837-844.
MLA	Li, Chun-Lu,et al."Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats".JOURNAL OF PSYCHOPHARMACOLOGY 27.9(2013):837-844.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000323644300009.（1184KB）			限制开放	Apache License	请求全文