The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study

	The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study
	Chen, Jie; Li, Xinying; McGue, Matt; Li, XY (reprint author), 16 Lincui Rd, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	BackgroundConfounding introduced by gene-environment correlation (rGE) may prevent one from observing a true gene-environment interaction (GxE) effect on psychopathology. The present study investigated the interacting effect of the BDNF Val66Met polymorphism and stressful life events (SLEs) on adolescent depression while controlling for the rGE by two means: separating pure environmental factors (independent SLEs) from the environmental factors under partial genetic control (dependent SLEs) and adopting a prospective longitudinal design. MethodsA total of 780 pairs of Chinese twins, aged 11-17years (mean=13.6, SD=1.8) at intake, were followed up twice. Self-reported depression symptoms at Time 1 and Time 2 were assessed by the Children's Depression Inventory (CDI). SLEs occurring between Time 1 and Time 2 were assessed by a self-reported checklist. SLEs were differentiated into independent and dependent ones and were validated by heritability analyses using twin design. The interacting effects between the BDNF Val66Met polymorphism and numbers of SLEs (total SLEs and independent SLEs) on intraindividual change of depression symptoms were examined. ResultsAfter controlling for sex, age, age square, and Time 1 depression, both total SLEs x BDNF Val66Met genotype and independent SLEs x BDNF Val66Met genotype significantly predicted Time 2 depression. Val allele carriers (Val/Val and Val/Met) were more susceptible to the detrimental effects of stress. ConclusionsThere is a true GxE effect underlying the observed interaction between BDNF Val66Met polymorphism and environmental stress on depression.
关键词	Adolescent depressive symptoms BDNF Val66Met polymorphism stressful life events gene-environment interaction gene-environment correlation
学科领域	Personality Psychology,Developmental Psychology
	2013
语种	英语
发表期刊	JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
ISSN	0021-9630
卷号	54 期号:10 页码:1066-1073
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This study was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8), Funds for young scholars of Institute of Psychology, Chinese Academy of Science (Y0CX351S01), and the National Natural Science Foundation of China (31170993). This research was also supported by Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号	WOS:000326177200006
资助机构	Chinese Academy of Sciences [KSCX2-EW-J-8] ; Funds for young scholars of Institute of Psychology, Chinese Academy of Science [Y0CX351S01] ; National Natural Science Foundation of China [31170993] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10681
专题	中国科学院心理健康重点实验室
通讯作者	Li, XY (reprint author), 16 Lincui Rd, Beijing 100101, Peoples R China.
作者单位	Li, XY (reprint author), 16 Lincui Rd, Beijing 100101, Peoples R China.
推荐引用方式 GB/T 7714	Chen, Jie,Li, Xinying,McGue, Matt,et al. The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study[J]. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY,2013,54(10):1066-1073.
APA	Chen, Jie,Li, Xinying,McGue, Matt,&Li, XY .(2013).The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study.JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY,54(10),1066-1073.
MLA	Chen, Jie,et al."The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene-environment correlation: evidence from a longitudinal twin study".JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY 54.10(2013):1066-1073.

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