Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis

	Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis
	Qian, Gui-min 2; Pan, Guo-Feng 3; Guo, Jian-You1 ; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
心理所单位排序	3
摘要	The anti-inflammatory and antinociceptive activities of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, were studied. The effects of cordymin on cytokine levels and total antioxidant activity were analysed. The antinociceptive effects of cordymin in vivo and in vitro were also determined. Cordymin treatment decreased the levels of tumour necrosis factor alpha, interleukin 1 beta and total antioxidant status. Cordymin inhibited the acetic acid-induced abdominal constrictions in mice in a dose-dependent manner. In the hot-plate test, results showed that cordymin significantly inhibited the reaction time to thermal stimuli at 30, 60 and 90 min. In neurolysin inhibition assay, cordymin showed strong activities against neurolysin (IC50 = 0.1 mu M). Our results show that cordymin is a potent anti-inflammatory and analgesic medicine.
关键词	cordymin anti-inflammatory antinociceptive TNF-alpha IL-1 beta TAOS neurolysin
学科领域	Medical Psychology
	2012
语种	英语
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	26 期号:24 页码:2358-2362
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This project was supported by NNSF grant (30800301, 31170992), the Key New Drugs Innovation project from Ministry of Science and Technology (2010ZX09102-201-018), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS记录号	WOS:000310608200013
资助机构	NNSF [30800301, 31170992] ; Ministry of Science and Technology [2010ZX09102-201-018] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8]
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11405
专题	中国科学院心理健康重点实验室
通讯作者	Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Zhejiang Pharmaceut Coll, Dept Tradit Chinese Med, Ningbo 315100, Zhejiang, Peoples R China 3.Capital Med Univ, Beijing Shijitan Hosp, Dept Tradit Chinese Med, Beijing 100038, Peoples R China
推荐引用方式 GB/T 7714	Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You,et al. Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis[J]. NATURAL PRODUCT RESEARCH,2012,26(24):2358-2362.
APA	Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You,&Guo, JY .(2012).Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis.NATURAL PRODUCT RESEARCH,26(24),2358-2362.
MLA	Qian, Gui-min,et al."Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis".NATURAL PRODUCT RESEARCH 26.24(2012):2358-2362.

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