Anterior insular cortex is necessary for empathetic pain perception

	Anterior insular cortex is necessary for empathetic pain perception
	Gu, Xiaosi; Gao, Zhixian; Wang, Xingchao; Liu, Xun; Knight, Robert T.; Hof, Patrick R.; Fan, Jin; Fan, J (reprint author), CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA.
心理所单位排序	5
摘要	Empathy refers to the ability to perceive and share another person's affective state. Much neuroimaging evidence suggests that observing others' suffering and pain elicits activations of the anterior insular and the anterior cingulate cortices associated with subjective empathetic responses in the observer. However, these observations do not provide causal evidence for the respective roles of anterior insular and anterior cingulate cortices in empathetic pain. Therefore, whether these regions are 'necessary' for empathetic pain remains unknown. Herein, we examined the perception of others' pain in patients with anterior insular cortex or anterior cingulate cortex lesions whose locations matched with the anterior insular cortex or anterior cingulate cortex clusters identified by a meta-analysis on neuroimaging studies of empathetic pain perception. Patients with focal anterior insular cortex lesions displayed decreased discrimination accuracy and prolonged reaction time when processing others' pain explicitly and lacked a typical interference effect of empathetic pain on the performance of a pain-irrelevant task. In contrast, these deficits were not observed in patients with anterior cingulate cortex lesions. These findings reveal that only discrete anterior insular cortex lesions, but not anterior cingulate cortex lesions, result in deficits in explicit and implicit pain perception, supporting a critical role of anterior insular cortex in empathetic pain processing. Our findings have implications for a wide range of neuropsychiatric illnesses characterized by prominent deficits in higher-level social functioning.
关键词	anterior cingulate cortex anterior insular cortex empathy meta-analysis necessity
学科领域	Perception Psychology，physiological Psychology/biological Psychology
	2012
语种	英语
发表期刊	BRAIN
ISSN	0006-8950
卷号	135 页码:2726-2735
期刊论文类型	期刊论文
URL	查看原文
收录类别	SSCI
项目简介	The National Institute of Health (NIH) (grants R21 MH083164 to J.F. and NS21135 to R. T. K), the James S. McDonnell Foundation (grant 22002078 to P. R. H.), and a Brain and Behavior Research Foundation NARSAD young investigator award (to X.L.).
WOS记录号	WOS:000308873600014
资助机构	National Institute of Health (NIH) [R21 MH083164, NS21135] ; James S. McDonnell Foundation [22002078] ; Brain and Behavior Research Foundation NARSAD
引用统计	被引频次：159[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14290
专题	中国科学院行为科学重点实验室
通讯作者	Fan, J (reprint author), CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA.
推荐引用方式 GB/T 7714	Gu, Xiaosi,Gao, Zhixian,Wang, Xingchao,et al. Anterior insular cortex is necessary for empathetic pain perception[J]. BRAIN,2012,135:2726-2735.
APA	Gu, Xiaosi.,Gao, Zhixian.,Wang, Xingchao.,Liu, Xun.,Knight, Robert T..,...&Fan, J .(2012).Anterior insular cortex is necessary for empathetic pain perception.BRAIN,135,2726-2735.
MLA	Gu, Xiaosi,et al."Anterior insular cortex is necessary for empathetic pain perception".BRAIN 135(2012):2726-2735.

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