A Brain Signature to Differentiate Acute and Chronic Pain in Rats

doi:10.3389/fncom.2016.00041

	A Brain Signature to Differentiate Acute and Chronic Pain in Rats
	Guo, Yifei1,2 ; Wang, Yuzheng1,2 ; Sun, Yabin1,2 ; Wang, Jin-Yan1
摘要	The transition from acute pain to chronic pain entails considerable changes of patients at multiple levels of the nervous system and in psychological states. An accurate differentiation between acute and chronic pain is essential in pain management as it may help optimize analgesic treatments according to the pain state of patients. Given that acute and chronic pain could modulate brain states in different ways and that brain states could greatly shape the neural processing of external inputs, we hypothesized that acute and chronic pain would show differential effects on cortical responses to non-nociceptive sensory information. Here by analyzing auditory-evoked potentials (AEPs) to pure tones in rats with acute or chronic pain, we found opposite influences of acute and chronic pain on cortical responses to auditory inputs. In particular, compared to no-pain controls, the N100 wave of rat AEPs was significantly enhanced in rats with acute pain but significantly reduced in rats with chronic pain, indicating that acute pain facilitated cortical processing of auditory information while chronic pain exerted an inhibitory effect. These findings could be justified by the fact that individuals suffering from acute or chronic pain would have different vigilance states, i.e., the vigilance level to external sensory stimuli would be increased with acute pain, but decreased with chronic pain. Therefore, this auditory response holds promise of being a brain signature to differentiate acute and chronic pain. Instead of investigating the pain system per se, the study of pain-induced influences on cortical processing of non-nocicpetive sensory information might represent a potential strategy to monitor the progress of pain chronification in clinical applications.
关键词	Acutepain Chronic Pain Auditory-evoked Potentials (Aeps) Sensory Processing Animal Models
	2016-04-28
语种	英语
DOI	10.3389/fncom.2016.00041
发表期刊	FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
ISSN	1662-5188
卷号	10 期号:0 页码:41
期刊论文类型	Article
收录类别	SCI
WOS关键词	EVENT-RELATED POTENTIALS ; CLINICAL-PRACTICE GUIDELINE ; AUDITORY-EVOKED-POTENTIALS ; CHRONIC BACK-PAIN ; SOCIETY/AMERICAN COLLEGE ; COGNITIVE PERFORMANCE ; INTENSITY DEPENDENCE ; CORTICAL POTENTIALS ; MISMATCH NEGATIVITY ; SLEEP-DEPRIVATION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Mathematical & Computational Biology ; Neurosciences & Neurology
WOS类目	Mathematical & Computational Biology ; Neurosciences
WOS记录号	WOS:000374922300001
资助机构	National Natural Science Foundation of China (NSFC)(31271092) ; Youth Innovation Promotion Association of the Chinese Academy of Sciences
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/19982
专题	中国科学院心理健康重点实验室健康与遗传心理学研究室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Sch Humanities, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Guo, Yifei,Wang, Yuzheng,Sun, Yabin,et al. A Brain Signature to Differentiate Acute and Chronic Pain in Rats[J]. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,2016,10(0):41.
APA	Guo, Yifei,Wang, Yuzheng,Sun, Yabin,&Wang, Jin-Yan.(2016).A Brain Signature to Differentiate Acute and Chronic Pain in Rats.FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,10(0),41.
MLA	Guo, Yifei,et al."A Brain Signature to Differentiate Acute and Chronic Pain in Rats".FRONTIERS IN COMPUTATIONAL NEUROSCIENCE 10.0(2016):41.

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