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The Weakened Relationship Between Prestimulus Alpha Oscillations and Response Time in Older Adults With Mild Cognitive Impairment | |
Chen, Yiqi1,2; He, Hao1,2,3,4; Xu, Pengfei1,2,3,4; Wang, Jing1,2; Qiu, Yuehong1,2; Feng, Wei5; Luo, Yuejia1,2,3,4; Hu, Li6; Guan, Qing1,2,3,4 | |
第一作者 | Chen, Yiqi |
通讯作者邮箱 | li hu [email protected] ; qing guan [email protected] |
心理所单位排序 | 6 |
摘要 | Background: Prestimulus alpha oscillations associated with preparatory attention have an impact on response time (RT). However, little is known about whether there is a deficit in the relationship between prestimulus alpha oscillations and RT in older adults with mild cognitive impairment (MCI). Method: We collected electroencephalography (EEG) data from 28 older adults with MCI and 28 demographically matched healthy controls (HCs) when they were performing an Eriksen flanker task. For each participant, single-trial prestimulus alpha power was calculated for combinations of congruency (congruent vs. incongruent) and response speed (fast vs. slow). Result: Statistical analysis indicated that prestimulus alpha power was significantly lower for fast trials than slow trials in HCs but not in older adults with MCI. The Fisher's z scores of the within-subject correlation coefficients between single-trial prestimulus alpha power and RT were significantly larger in HCs than in older adults with MCI. In addition, machine learning analyses indicated that prestimulus alpha power and its correlation with RT could serve as features to distinguish older adults with MCI from HCs and to predict performance on some neuropsychological tests. Conclusion: The reduced correlation between prestimulus alpha activity and RT suggests that older adults with MCI experience impaired preparatory attention. |
关键词 | mild cognitive impairment preparatory attention prestimulus alpha oscillations response time machine learning |
2020-03-12 | |
语种 | 英语 |
DOI | 10.3389/fnhum.2020.00048 |
发表期刊 | FRONTIERS IN HUMAN NEUROSCIENCE |
ISSN | 1662-5161 |
卷号 | 14页码:10 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Key Research and Development Program of China[2018YFC1315202] ; National Key Research and Development Program of China[2018YFC1315205] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions grant[2019SHIBS0003] ; Shenzhen Science and Technology Research Funding Program[JCYJ20180507183500566] ; National Natural Science Foundation of China[31700960] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | TOP-DOWN MODULATION ; PRE-STIMULUS ALPHA ; ALZHEIMERS-DISEASE ; PREPARATORY ATTENTION ; EEG ; BRAIN ; PERFORMANCE ; INHIBITION ; DEMENTIA ; PREDICT |
WOS研究方向 | Neurosciences & Neurology ; Psychology |
WOS类目 | Neurosciences ; Psychology |
WOS记录号 | WOS:000525489300001 |
Q分类 | Q2 |
资助机构 | National Key Research and Development Program of China ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions grant ; Shenzhen Science and Technology Research Funding Program ; National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/31559 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Hu, Li; Guan, Qing |
作者单位 | 1.Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, Shenzhen, Peoples R China 2.Shenzhen Univ, Sch Psychol, Shenzhen, Peoples R China 3.Shenzhen Fundamental Res Inst, Shenzhen Hong Kong Inst Brain Sci, Shenzhen, Peoples R China 4.Shenzhen Inst Neurosci, Ctr Neuroimaging, Shenzhen, Peoples R China 5.Jilin Med Univ, Sch Marxism, Jilin, Jilin, Peoples R China 6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Chen, Yiqi,He, Hao,Xu, Pengfei,et al. The Weakened Relationship Between Prestimulus Alpha Oscillations and Response Time in Older Adults With Mild Cognitive Impairment[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2020,14:10. |
APA | Chen, Yiqi.,He, Hao.,Xu, Pengfei.,Wang, Jing.,Qiu, Yuehong.,...&Guan, Qing.(2020).The Weakened Relationship Between Prestimulus Alpha Oscillations and Response Time in Older Adults With Mild Cognitive Impairment.FRONTIERS IN HUMAN NEUROSCIENCE,14,10. |
MLA | Chen, Yiqi,et al."The Weakened Relationship Between Prestimulus Alpha Oscillations and Response Time in Older Adults With Mild Cognitive Impairment".FRONTIERS IN HUMAN NEUROSCIENCE 14(2020):10. |
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