中国科学院心理研究所机构知识库

目的:探索用长效纳曲酮缓释剂(Long-term sustained release naltrexone,LSRNTX)治疗阿片类药物依赖者半年后对其图片记忆能力的影响。方法:本研究设计为对比观察。用长效纳曲酮缓释剂治疗6个月以上的阿片依赖综合征患者35人为实验组,设置三个对照组,即戒毒时间相同但不用药物治疗的强制戒毒组(n=26)、未戒毒的阿片依赖对照组(n=27)和正常对照组(n=22)。现场采集记录所有被试对随机序列呈现的新旧图片进行再认时产生的脑电ERP(Event Related Potential)波形。结果:(1)图片记忆的反应时四组间差异有统计学意义(F=19.030,P<0.001),两两比较显示正常对照组的图片记忆反应时最短[(1035.3±89.2)ms],LSRNTX治疗组的反应时短于强制戒毒组和阿片依赖对照组[(1128.5±90.2)msvs.(1240.0±87.3)ms,(1380.1±132.9)ms]。图片的记忆正确率四组间差异有统计学意义(96.27%,92.97%,90.04%,89.93%;P<0.001)。(2)图片记忆的P200潜伏期四组间差异有统计学意义(F=9.247,P<0.001),两两比较显示正常对照组[(176.0±20.5)ms]、LSRNTX治疗组[(180.7±21.4)ms]的P200潜伏期均短于强制戒毒组[(201.4±22.3)ms]和阿片依赖对照组[(206.6±33.3)ms](均P<0.001)。(3)Fz点P200波幅四组差异有统计学意义(F=6.666,P<0.001),LSRNTX治疗后波幅显著提高到6.35μV。结论:LSRNTX治疗后的阿片类药物依赖患者的脑电ERP波形有所恢复,患者的图片记忆能力也同样提高。

Objective： To explore the effects of long-term sustained release naltrexone （LSRNTX） treatment on image memory in patients with opioid dependence. Methods： The patients with opioid dependence were divided into three groups： LSRNTX treated group, incarcerated abstinent group and non-treated group, matched by a healthy control group. All subjects were recorded scalp event related potential （ERP） when they performed image recognition. Results： （1） Reaction time （RT） in three patient groups were longer than that in healthy control group [ RT in healthy control group, LSRNTX treated group, abstinent group and non-treated group were （1035.3 ± 89. 2） ms, （ 1128.5 ± 90. 2） ms, （ 1240 ± 87.3 ） ms, and （ 1380. 1 ± 132. 9 ） ms respectively ; P 〈 0. 001 ], and the accuracy rate in healthy control was the highest （ accuracy rate in healthy control group, LSRNTX treated group, abstinent group and non-treated group were 96. 27%, 92. 97%, 90.04% and 89. 93% respectively; P 〈0. 001 ） . （2） There were significant differences in latencies of P200 for recognition memory among the four groups [ （ 176. 00 ± 20. 45 ） ms, （180.73 ±21.41） ms, （201.36±22.29） ms, and （206.55 ±33.31） ms respectively; P〈0.001] . Latency of P200 in LSRNTX treated group did not significantly differ from that in healthy control group （ P 〉 0.05 ） . （ 3 ） There were significantly differences in wave amplitude of P200 among the four groups [ （4. 22 ±3.06） μV, （6. 35 ±3.47） μV , （4.42 ± 2. 62 ） μV and （ 3.74 ± 3.30） μV respectively ; P 〈 0. 001 ] . The wave amplitude of LSRNTX treated group increased to 6. 35 μV. Conclusion： Long-term sustained release naltrexone treatment may improve the function of nervous system of opioid addicts and improve their image memory.

广东省科技计划项目(2004B36001075) 广东省医学科学基金(A2007592)