Cortical language activation in aphasia: a functional MRI study

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	Cortical language activation in aphasia: a functional MRI study
	Xu, XJ ; Zhang, MM ; Shang, DS ; Wang, QD ; Luo, BY ; Weng, XC ; M. M. Zhang
摘要	Background Functional neuroimaging has been used in neurolinguistic research on normal subjects and on patients with brain damage. This study was designed to investigate the differences of the neural basis underlying language processing between normal subjects and aphasics. Methods Functional magnetic resonance imaging (fMRI) was used to map the language network in 6 normal subjects and 3 patients with aphasia who were in the stage of recovery from acute stroke. The participants performed a word generation task during multi-slice functional scanning for the measurement of signal change associated with regional neural activity induced by the task. Results In normal subjects, a distributed language network was activated. Activations were present in the frontal, temporal, parietal and occipital regions. In the patient group, however, no activation was detected in the left inferior frontal gyrus whether the patient had a lesion in the left frontal lobe or not. Two patients showed activations in some right hemisphere regions where no activation appeared in normal subjects. Conclusions fMRI with word generation task is feasible for evaluating language function in aphasic patients. Remote effect of focal lesion and functional redistribution or reorganisation can be found in aphasic patients.; Background Functional neuroimaging has been used in neurolinguistic research on normal subjects and on patients with brain damage. This study was designed to investigate the differences of the neural basis underlying language processing between normal subjects and aphasics.
关键词	aphasia magnetic resonance imaging functional language human brain mapping
学科领域	认知神经科学 ; 心理语言学
	2004-07-01
语种	英语
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	117 期号:7 页码:1011-1016
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000223074200010
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5277
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	M. M. Zhang
作者单位	1.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurol, Hangzhou 310003, Peoples R China 2.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Radiol, Hangzhou 310003, Peoples R China 3.Acad Sinica, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Xu, XJ,Zhang, MM,Shang, DS,et al. Cortical language activation in aphasia: a functional MRI study[J]. CHINESE MEDICAL JOURNAL,2004,117(7):1011-1016.
APA	Xu, XJ.,Zhang, MM.,Shang, DS.,Wang, QD.,Luo, BY.,...&M. M. Zhang.(2004).Cortical language activation in aphasia: a functional MRI study.CHINESE MEDICAL JOURNAL,117(7),1011-1016.
MLA	Xu, XJ,et al."Cortical language activation in aphasia: a functional MRI study".CHINESE MEDICAL JOURNAL 117.7(2004):1011-1016.

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